2013年5月3日，醫科院動研所衛生部人類疾病比較醫學中心的楊亞軍博士發表了題目為“Chebulagic Acid, a Hydrolyzable Tannin, Exhibited Antiviral Activity in Vitro and in Vivo against Human Enterovirus 71”，報告了人EV71病毒體內體外實驗中，一種酸性藥物對病毒活性的影響。通訊作者為張連峰教授。
全文網址：http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676802/pdf/ijms-14-09618.pdf
英文摘要：
Int J Mol Sci. 2013 May 3;14(5):9618-27. doi: 10.3390/ijms14059618.
Chebulagic Acid, a Hydrolyzable Tannin, Exhibited Antiviral Activity in Vitro and in Vivo against Human Enterovirus 71.
Yang Y, Xiu J, Liu J, Zhang L, Li X, Xu Y, Qin C, Zhang L.
Source
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, PUMC, Beijing 100021, China. [email protected].
Abstract
Human enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. Presently, no vaccines or antiviral drugs have been clinically available to employ against EV71. In this study, we demonstrate that treatment with chebulagic acid reduced the viral cytopathic effect on rhabdomyosarcoma cells with an IC50 of 12.5 μg/mL. The utilization of the chebulagic acid treatment on mice challenged with a lethal dose of enterovirus 71 was able to efficiently reduce mortality and relieve clinical symptoms through the inhibition of viral replication. Chebulagic acid may represent a potential therapeutic agent to control infections to enterovirus 71.
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